› 2a3y

X-ray diffraction
2Å resolution

Pentameric crystal structure of human serum amyloid P-component bound to Bis-1,2-{[(Z)-2carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane.

Released:
DOI: 10.2210/pdb2a3y/pdb
PDB entry 2a3y coloured by chain, front view.
PDB entry 2a3y coloured by chain, side view.
PDB entry 2a3y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Ligand-assisted aggregation of proteins. Dimerization of serum amyloid P component by bivalent ligands.
Ho JG, Kitov PI, Paszkiewicz E, Sadowska J, Bundle DR, Ng KK
J Biol Chem 280 31999-2008 (2005)
PMID: 16036920

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136123 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serum amyloid P-component Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 204 amino acids
Theoretical weight: 23.28 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02743 (Residues: 20-223; Coverage: 100%)
Gene names: APCS, PTX2
Sequence domains: Pentaxin family
Structure domains: Jelly Rolls

Ligands and Environments

2 bound ligands:
Ligand CA 10 x CA
Ligand CPJ 5 x CPJ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P21
Unit cell:
a: 94.715Å b: 69.956Å c: 101.367Å
α: 90° β: 97.09° γ: 90°
R-values:
R R work R free
0.217 0.216 0.25

Quick links

Citations

2 review citations

Bacterial toxin inhibitors based on multivalent scaffolds.
Branson et al. (2013)
1 more

2 mentions without citation

Goodpasture antigen-binding protein/ceramide transporter binds to human serum amyloid P-component and is present in brain amyloid plaques.
Mencarelli et al. (2012)
1 more