Function and Biology Details
Reaction catalysed:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Fibrinogen, alpha/beta/gamma chain, coiled coil domain
- Prothrombin/thrombin
- Peptidase S1A, chymotrypsin family
- Serine proteases, trypsin domain
- Peptidase S1, PA clan, chymotrypsin-like fold
- Fibrinogen
- Serine proteases, trypsin family, serine active site
- Serine proteases, trypsin family, histidine active site
3 more domains
Structure analysis Details
Assembly composition:
hetero decamer (preferred)
Assembly name:
Fibrinogen complex and Thrombin heavy chain (preferred)
PDBe Complex ID:
PDB-CPX-133150 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):