› 2a4c

X-ray diffraction
2.9Å resolution

Crystal structure of mouse cadherin-11 EC1

Released:
DOI: 10.2210/pdb2a4c/pdb
PDB entry 2a4c coloured by chain, front view.
PDB entry 2a4c coloured by chain, side view.
PDB entry 2a4c coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Type II cadherin ectodomain structures: implications for classical cadherin specificity.
Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L
Cell 124 1255-68 (2006)
PMID: 16564015

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157293 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 99 amino acids
Theoretical weight: 11.06 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P55288 (Residues: 54-151; Coverage: 13%)
Gene names: Cad-11, Cdh11
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P3221
Unit cell:
a: 76.937Å b: 76.937Å c: 102.317Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.204 0.252
Expression system: Escherichia coli BL21

Quick links

Citations

56 review citations

Adherens and tight junctions: structure, function and connections to the actin cytoskeleton.
Hartsock et al. (2008)
55 more

5 mentions without citation

Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins.
Vendome et al. (2011)
4 more