› 2a5s

X-ray diffraction
1.7Å resolution

Crystal Structure Of The NR2A Ligand Binding Core In Complex With Glutamate

Released:
DOI: 10.2210/pdb2a5s/pdb
PDB entry 2a5s coloured by chain, front view.
PDB entry 2a5s coloured by chain, side view.
PDB entry 2a5s coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Subunit arrangement and function in NMDA receptors.
Furukawa H, Singh SK, Mancusso R, Gouaux E
Nature 438 185-92 (2005)
PMID: 16281028

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-169490 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, NMDA 2A Chain: A
Molecule details ›
Chain: A
Length: 284 amino acids
Theoretical weight: 31.85 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q00959 (Residues: 401-802; Coverage: 20%)
Gene name: Grin2a
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:
Ligand GLU 1 x GLU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P41212
Unit cell:
a: 52.106Å b: 52.106Å c: 198.675Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.196 0.223
Expression system: Escherichia coli

Quick links

Citations

106 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
105 more

22 mentions without citation

Protein-protein docking benchmark version 4.0.
Hwang et al. (2010)
21 more