› 2a62

X-ray diffraction
4.5Å resolution

Crystal structure of mouse cadherin-8 EC1-3

Released:
DOI: 10.2210/pdb2a62/pdb
PDB entry 2a62 coloured by chain, front view.
PDB entry 2a62 coloured by chain, side view.
PDB entry 2a62 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Type II cadherin ectodomain structures: implications for classical cadherin specificity.
Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L
Cell 124 1255-68 (2006)
PMID: 16564015

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161284 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-8 Chain: A
Molecule details ›
Chain: A
Length: 322 amino acids
Theoretical weight: 35.3 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P97291 (Residues: 63-383; Coverage: 42%)
Gene name: Cdh8
Sequence domains: Cadherin domain

Ligands and Environments

1 bound ligand:
Ligand CA 6 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P4122
Unit cell:
a: 75.818Å b: 75.818Å c: 233.76Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.276 0.271 0.346
Expression system: Escherichia coli

Quick links

Citations

56 review citations

Adherens and tight junctions: structure, function and connections to the actin cytoskeleton.
Hartsock et al. (2008)
55 more

11 mentions without citation

Super-resolution biomolecular crystallography with low-resolution data.
Schröder et al. (2010)
10 more