› 2a7w

X-ray diffraction
2.8Å resolution

Crystal Structure of Phosphoribosyl-ATP Pyrophosphatase from Chromobacterium violaceum (ATCC 12472). NESG TARGET CVR7

Released:
DOI: 10.2210/pdb2a7w/pdb
PDB entry 2a7w coloured by chain, front view.
PDB entry 2a7w coloured by chain, side view.
PDB entry 2a7w coloured by chain, top view.
Source organism: Chromobacterium violaceum
Entry authors: Benach J, Forouhar F, Kuzin AP, Abashidze M, Vorobiev SM, Rong X, Acton TB, Montelione GT, Hunt JF, Northeast Structural Genomics Consortium (NESG)

Function and Biology Details

Reaction catalysed: 
1-(5-phospho-beta-D-ribosyl)-ATP + H(2)O = 1-(5-phospho-beta-D-ribosyl)-AMP + diphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181860 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphoribosyl-ATP pyrophosphatase Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 116 amino acids
Theoretical weight: 13.42 KDa
Source organism: Chromobacterium violaceum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7P0E6 (Residues: 1-108; Coverage: 100%)
Gene names: CV_0621, hisE
Sequence domains: Phosphoribosyl-ATP pyrophosphohydrolase
Structure domains: MazG-like

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 48 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21
Unit cell:
a: 97.938Å b: 67.544Å c: 113.512Å
α: 90° β: 92.45° γ: 90°
R-values:
R R work R free
0.258 0.258 0.28
Expression system: Escherichia coli

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