› 2a9x

Solution NMR

TAR RNA recognition by a cyclic peptidomimetic of Tat protein

Released:
DOI: 10.2210/pdb2a9x/pdb
PDB entry 2a9x coloured by chain, ensemble of 10 models, front view.
PDB entry 2a9x coloured by chain, ensemble of 10 models, side view.
PDB entry 2a9x coloured by chain, ensemble of 10 models, top view.
Source organism: Synthetic construct
Primary publication:
TAR RNA recognition by a cyclic peptidomimetic of Tat protein.
Leeper TC, Athanassiou Z, Dias RL, Robinson JA, Varani G
Biochemistry 44 12362-72 (2005)
PMID: 16156649

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-162618 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
BIV-2 cyclic peptide Chain: 1
Molecule details ›
Chain: 1
Length: 14 amino acids
Theoretical weight: 1.75 KDa
Source organism: Synthetic construct
Expression system: Not provided
BIV TAR RNA Chain: 2
Molecule details ›
Chain: 2
Length: 28 nucleotides
Theoretical weight: 8.92 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Torsion Angle Molecular Dynamics
Expression system: Not provided

Quick links

Citations

5 review citations

Structure determination and dynamics of protein-RNA complexes by NMR spectroscopy.
Dominguez et al. (2011)
4 more

8 mentions without citation

Face-time with TAR: Portraits of an HIV-1 RNA with diverse modes of effector recognition relevant for drug discovery.
Chavali et al. (2019)
7 more