› 2acg

X-ray diffraction
2.5Å resolution

ACANTHAMOEBA CASTELLANII PROFILIN II

Released:
DOI: 10.2210/pdb2acg/pdb
PDB entry 2acg coloured by chain, front view.
PDB entry 2acg coloured by chain, side view.
PDB entry 2acg coloured by chain, top view.
Source organism: Acanthamoeba castellanii
Primary publication:
X-ray structures of isoforms of the actin-binding protein profilin that differ in their affinity for phosphatidylinositol phosphates.
Fedorov AA, Magnus KA, Graupe MH, Lattman EE, Pollard TD, Almo SC
Proc Natl Acad Sci U S A 91 8636-40 (1994)
PMID: 8078936

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148814 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Profilin-2 Chain: A
Molecule details ›
Chain: A
Length: 125 amino acids
Theoretical weight: 12.94 KDa
Source organism: Acanthamoeba castellanii
Expression system: Not provided
UniProt:
  • Canonical: P19984 (Residues: 2-126; Coverage: 99%)
Sequence domains: Profilin
Structure domains: Dynein light chain 2a, cytoplasmic

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 86.535Å b: 47.951Å c: 34.753Å
α: 90° β: 103.78° γ: 90°
R-values:
R R work R free
0.182 0.182 not available
Expression system: Not provided

Quick links

Citations

6 review citations

The role of profilin complexes in cell motility and other cellular processes.
Witke W. (2004)
5 more

2 mentions without citation

Incompatibility with formin Cdc12p prevents human profilin from substituting for fission yeast profilin: insights from crystal structures of fission yeast profilin.
Ezezika et al. (2009)
1 more