› 2adq

X-ray diffraction
2.4Å resolution

Human Manganese Superoxide Dismutase

Released:
DOI: 10.2210/pdb2adq/pdb
PDB entry 2adq coloured by chain, front view.
PDB entry 2adq coloured by chain, side view.
PDB entry 2adq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of nitrated human manganese superoxide dismutase: mechanism of inactivation.
Quint P, Reutzel R, Mikulski R, McKenna R, Silverman DN
Free Radic Biol Med 40 453-8 (2006)
PMID: 16443160

Function and Biology Details

Reaction catalysed: 
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137484 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Superoxide dismutase [Mn], mitochondrial Chain: B
Molecule details ›
Chain: B
Length: 198 amino acids
Theoretical weight: 22.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04179 (Residues: 25-222; Coverage: 89%)
Gene name: SOD2
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand MN 1 x MN
Ligand K 1 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P6122
Unit cell:
a: 81.159Å b: 81.159Å c: 242.165Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.217 0.217 0.24
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Peroxynitrite, a stealthy biological oxidant.
Radi R. (2013)
11 more

10 mentions without citation

Tyrosine modifications in aging.
Feeney et al. (2012)
9 more