› 2ahx

X-ray diffraction
2.4Å resolution

Crystal structure of ErbB4/HER4 extracellular domain

Released:
DOI: 10.2210/pdb2ahx/pdb
PDB entry 2ahx coloured by chain, front view.
PDB entry 2ahx coloured by chain, side view.
PDB entry 2ahx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand.
Bouyain S, Longo PA, Li S, Ferguson KM, Leahy DJ
Proc Natl Acad Sci U S A 102 15024-9 (2005)
PMID: 16203964

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-172255 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor tyrosine-protein kinase erbB-4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 617 amino acids
Theoretical weight: 69.03 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q15303 (Residues: 26-641; Coverage: 48%)
Gene names: ERBB4, HER4
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand NAG 16 x NAG
Ligand SO4 3 x SO4
Ligand YT3 1 x YT3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: C2221
Unit cell:
a: 76.96Å b: 203.09Å c: 261.32Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.235 0.265
Expression system: Cricetulus griseus

Quick links

Citations

35 review citations

Cell signaling by receptor tyrosine kinases.
Lemmon et al. (2010)
34 more

10 mentions without citation

Structure-based view of epidermal growth factor receptor regulation.
Ferguson KM. (2008)
9 more