› 2al5

X-ray diffraction
1.65Å resolution

Crystal structure of the GluR2 ligand binding core (S1S2J) in complex with fluoro-willardiine and aniracetam

Released:
DOI: 10.2210/pdb2al5/pdb
PDB entry 2al5 coloured by chain, front view.
PDB entry 2al5 coloured by chain, side view.
PDB entry 2al5 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Mechanism of positive allosteric modulators acting on AMPA receptors.
Jin R, Clark S, Weeks AM, Dudman JT, Gouaux E, Partin KM
J Neurosci 25 9027-36 (2005)
PMID: 16192394

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 263 amino acids
Theoretical weight: 29.22 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19491 (Residues: 413-796; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand FWD 2 x FWD
Ligand 4MP 1 x 4MP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21
Unit cell:
a: 48.056Å b: 64.126Å c: 107.949Å
α: 90° β: 90.07° γ: 90°
R-values:
R R work R free
0.197 0.197 0.22
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

30 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
29 more

7 mentions without citation

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Hansen et al. (2021)
6 more