› 2al6

X-ray diffraction
2.35Å resolution

FERM domain of Focal Adhesion Kinase

Released:
DOI: 10.2210/pdb2al6/pdb
PDB entry 2al6 coloured by chain, front view.
PDB entry 2al6 coloured by chain, side view.
PDB entry 2al6 coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Crystal structure of the FERM domain of focal adhesion kinase.
Ceccarelli DF, Song HK, Poy F, Schaller MD, Eck MJ
J Biol Chem 281 252-9 (2006)
PMID: 16221668

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169484 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Focal adhesion kinase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 375 amino acids
Theoretical weight: 43.01 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q00944 (Residues: 31-405; Coverage: 36%)
Gene names: FAK, FAK1, PTK2
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-ID-B
Spacegroup: P212121
Unit cell:
a: 50.54Å b: 123.99Å c: 133.93Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.215 0.252
Expression system: Escherichia coli

Quick links

Citations

27 review citations

Integrin-regulated FAK-Src signaling in normal and cancer cells.
Mitra et al. (2006)
26 more

25 mentions without citation

FAK Structure and Regulation by Membrane Interactions and Force in Focal Adhesions.
Tapial Martínez et al. (2020)
24 more