› 2ap9

X-ray diffraction
2.8Å resolution

Crystal structure of acetylglutamate kinase from Mycobacterium tuberculosis CDC1551

Released:
DOI: 10.2210/pdb2ap9/pdb
PDB entry 2ap9 coloured by chain, front view.
PDB entry 2ap9 coloured by chain, side view.
PDB entry 2ap9 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis CDC1551
Entry authors: Rajashankar KR, Kniewel R, Lee K, Lima CD, Burley SK, New York SGX Research Center for Structural Genomics (NYSGXRC)

Function and Biology Details

Reaction catalysed: 
ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162038 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acetylglutamate kinase Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 299 amino acids
Theoretical weight: 31.96 KDa
Source organism: Mycobacterium tuberculosis CDC1551
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WQ01 (Residues: 4-294; Coverage: 99%)
Gene names: MTCY06H11.19, Rv1654, argB
Sequence domains: Amino acid kinase family
Structure domains: Acetylglutamate kinase-like

Ligands and Environments

2 bound ligands:
Ligand MG 2 x MG
Ligand NI 1 x NI
1 modified residue:
Ligand MSE 42 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P212121
Unit cell:
a: 88.024Å b: 122.996Å c: 194.581Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.258 0.258 0.284
Expression system: Escherichia coli

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