› 2aql

X-ray diffraction
2.3Å resolution

Crystal Structure of the MRG15 MRG domain

Released:
DOI: 10.2210/pdb2aql/pdb
PDB entry 2aql coloured by chain, front view.
PDB entry 2aql coloured by chain, side view.
PDB entry 2aql coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain.
Bowman BR, Moure CM, Kirtane BM, Welschhans RL, Tominaga K, Pereira-Smith OM, Quiocho FA
Structure 14 151-8 (2006)
PMID: 16407074

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193678 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mortality factor 4-like protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 173 amino acids
Theoretical weight: 20.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UBU8 (Residues: 190-362; Coverage: 48%)
Gene names: FWP006, HSPC008, HSPC061, MORF4L1, MRG15, PP368
Sequence domains: MRG
Structure domains: MRG domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: R3
Unit cell:
a: 111.2Å b: 111.2Å c: 84.7Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.273 0.245 0.273
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Molecular Mechanisms of PALB2 Function and Its Role in Breast Cancer Management.
Wu et al. (2020)
4 more

1 mention without citation

Structural basis for molecular interactions involving MRG domains: implications in chromatin biology.
Xie et al. (2012)