› 2aqy

Solution NMR

(3+1) assembly of three human telomeric DNA repeats into an asymmetrical dimeric G-quadruplex

Released:
DOI: 10.2210/pdb2aqy/pdb
PDB entry 2aqy coloured by chain, ensemble of 10 models, front view.
PDB entry 2aqy coloured by chain, ensemble of 10 models, side view.
PDB entry 2aqy coloured by chain, ensemble of 10 models, top view.
Source organisms:
Primary publication:
(3 + 1) Assembly of three human telomeric repeats into an asymmetric dimeric G-quadruplex.
Zhang N, Phan AT, Patel DJ
J Am Chem Soc 127 17277-85 (2005)
PMID: 16332077

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115081 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
5'-D(*GP*(OIP)P*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*T)-3' Chain: A
Molecule details ›
Chain: A
Length: 16 nucleotides
Theoretical weight: 5.05 KDa
Source organism: Homo sapiens
Expression system: Not provided
5'-D(*TP*AP*GP*GP*GP*(DU))-3' Chain: B
Molecule details ›
Chain: B
Length: 6 nucleotides
Theoretical weight: 1.85 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry simulated annealing molecular dynamics matrix relaxation
Expression system: Not provided

Quick links

Citations

15 review citations

Quadruplex DNA: sequence, topology and structure.
Burge et al. (2006)
14 more

4 mentions without citation

Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.
Patel et al. (2007)
3 more