› 2ar7

X-ray diffraction
2.15Å resolution

Crystal structure of human adenylate kinase 4, AK4

Released:
DOI: 10.2210/pdb2ar7/pdb
PDB entry 2ar7 coloured by chain, front view.
PDB entry 2ar7 coloured by chain, side view.
PDB entry 2ar7 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Filippakopoulos P, Turnbull AP, Fedorov O, Weigelt J, Bunkoczi G, Ugochukwu E, Debreczeni J, Niesen F, von Delft F, Edwards A, Arrowsmith C, Sundstrom M, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed: 
NTP + AMP = NDP + ADP
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-150934 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenylate kinase 4, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 246 amino acids
Theoretical weight: 27.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P27144 (Residues: 1-223; Coverage: 100%)
Gene names: AK3, AK3L1, AK4
Sequence domains:
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2221
Unit cell:
a: 89.738Å b: 95.514Å c: 140.873Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.169 0.166 0.23
Expression system: Escherichia coli BL21(DE3)

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