› 2ari

Solution NMR

Solution structure of micelle-bound fusion domain of HIV-1 gp41

Released:
DOI: 10.2210/pdb2ari/pdb
PDB entry 2ari coloured by chain, ensemble of 30 models, front view.
PDB entry 2ari coloured by chain, ensemble of 30 models, side view.
PDB entry 2ari coloured by chain, ensemble of 30 models, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Structure and dynamics of micelle-associated human immunodeficiency virus gp41 fusion domain.
Jaroniec CP, Kaufman JD, Stahl SJ, Viard M, Blumenthal R, Wingfield PT, Bax A
Biochemistry 44 16167-80 (2005)
PMID: 16331977

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136938 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protein gp41 Chain: A
Molecule details ›
Chain: A
Length: 39 amino acids
Theoretical weight: 3.88 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03375 (Residues: 512-541; Coverage: 4%)
Gene name: env

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing molecular dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

17 review citations

Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme.
White et al. (2008)
16 more

4 mentions without citation

Mechanistic insights of host cell fusion of SARS-CoV-1 and SARS-CoV-2 from atomic resolution structure and membrane dynamics.
Chakraborty et al. (2020)
3 more