› 2asp

X-ray diffraction
1.64Å resolution

Structure of Rabbit Actin In Complex With Reidispongiolide C

Released:
DOI: 10.2210/pdb2asp/pdb
PDB entry 2asp coloured by chain, front view.
PDB entry 2asp coloured by chain, side view.
PDB entry 2asp coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Structures of microfilament destabilizing toxins bound to actin provide insight into toxin design and activity.
Allingham JS, Zampella A, D'Auria MV, Rayment I
Proc Natl Acad Sci U S A 102 14527-32 (2005)
PMID: 16192358

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159302 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Actin, alpha skeletal muscle Chain: A
Molecule details ›
Chain: A
Length: 375 amino acids
Theoretical weight: 41.86 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P68135 (Residues: 3-377; Coverage: 100%)
Gene names: ACTA, ACTA1
Sequence domains: Actin
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand CA 2 x CA
Ligand ATP 1 x ATP
Ligand RGC 1 x RGC
Ligand EDO 5 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 170.402Å b: 54.689Å c: 40.872Å
α: 90° β: 95.81° γ: 90°
R-values:
R R work R free
0.177 0.163 0.193

Quick links

Citations

11 review citations

Marine natural products.
Blunt et al. (2009)
10 more

10 mentions without citation

Actin structure and function.
Dominguez et al. (2011)
9 more