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X-ray diffraction
1.75Å resolution

X-RAY STRUCTURE OF cysteine dioxygenase type I FROM MUS MUSCULUS MM.241056

Released:
DOI: 10.2210/pdb2atf/pdb
PDB entry 2atf coloured by chain, front view.
PDB entry 2atf coloured by chain, side view.
PDB entry 2atf coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure and mechanism of mouse cysteine dioxygenase.
McCoy JG, Bailey LJ, Bitto E, Bingman CA, Aceti DJ, Fox BG, Phillips GN
Proc Natl Acad Sci U S A 103 3084-9 (2006)
PMID: 16492780

Function and Biology Details

Reaction catalysed: 
L-cysteine + O(2) = 3-sulfinoalanine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157996 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cysteine dioxygenase type 1 Chain: A
Molecule details ›
Chain: A
Length: 200 amino acids
Theoretical weight: 23.16 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P60334 (Residues: 2-200; Coverage: 100%)
Gene name: Cdo1
Sequence domains: Cysteine dioxygenase type I
Structure domains: Jelly Rolls

Ligands and Environments

2 bound ligands:
Ligand NI 1 x NI
Ligand EDO 1 x EDO
1 modified residue:
Ligand MSE 3 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P43212
Unit cell:
a: 57.55Å b: 57.55Å c: 122.076Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.179 0.216
Expression system: Escherichia coli

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Citations

16 review citations

Enzymology of H2S biogenesis, decay and signaling.
Kabil et al. (2014)
15 more

6 mentions without citation

Go it alone: four-electron oxidations by mononuclear non-heme iron enzymes.
Peck et al. (2017)
5 more