› 2avd

X-ray diffraction
1.7Å resolution

Crystal Structure of Human Catechol-O-methyltransferase domain containing 1

Released:
DOI: 10.2210/pdb2avd/pdb
PDB entry 2avd coloured by chain, front view.
PDB entry 2avd coloured by chain, side view.
PDB entry 2avd coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Min JR, Wu H, Zeng H, Loppnau P, Sundstrom M, Arrowsmith CH, Edwards AM, Bochkarev A, Plotnikov AN, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183219 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Catechol O-methyltransferase domain-containing protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 229 amino acids
Theoretical weight: 25.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86VU5 (Residues: 36-262; Coverage: 87%)
Gene names: COMTD1, UNQ766/PRO1558
Sequence domains: O-methyltransferase
Structure domains: Vaccinia Virus protein VP39

Ligands and Environments

1 bound ligand:
Ligand SAM 2 x SAM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21
Unit cell:
a: 51.882Å b: 65.222Å c: 61.799Å
α: 90° β: 102.66° γ: 90°
R-values:
R R work R free
0.174 0.172 0.213
Expression system: Escherichia coli

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