› 2avw

X-ray diffraction
2Å resolution

Crystal structure of monoclinic form of streptococcus Mac-1

Released:
DOI: 10.2210/pdb2avw/pdb
PDB entry 2avw coloured by chain, front view.
PDB entry 2avw coloured by chain, side view.
PDB entry 2avw coloured by chain, top view.
Source organism: Streptococcus pyogenes MGAS5005
Primary publication:
Crystal structure of group A streptococcus Mac-1: insight into dimer-mediated specificity for recognition of human IgG.
Agniswamy J, Nagiec MJ, Liu M, Schuck P, Musser JM, Sun PD
Structure 14 225-35 (2006)
PMID: 16472742

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181475 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ig protease IdeS domain-containing protein Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 311 amino acids
Theoretical weight: 35.09 KDa
Source organism: Streptococcus pyogenes MGAS5005
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7DAM2 (Residues: 30-339; Coverage: 100%)
Gene name: SPy_0861
Sequence domains: Mac 1
Structure domains: Cysteine proteinases

Ligands and Environments

2 bound ligands:
Ligand SO4 6 x SO4
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 106.986Å b: 65.464Å c: 137.244Å
α: 90° β: 105.81° γ: 90°
R-values:
R R work R free
0.224 0.218 0.267
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Streptococcal IdeS and its impact on immune response and inflammation.
von Pawel-Rammingen U. (2012)
18 other articles

3 mentions without citation

Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.
Liu et al. (2005)
2 more