› 2aw6

X-ray diffraction
3Å resolution

Structure of a bacterial peptide pheromone/receptor complex and its mechanism of gene regulation

Released:
DOI: 10.2210/pdb2aw6/pdb
PDB entry 2aw6 coloured by chain, front view.
PDB entry 2aw6 coloured by chain, side view.
PDB entry 2aw6 coloured by chain, top view.
Source organism: Enterococcus faecalis
Primary publication:
Structure of peptide sex pheromone receptor PrgX and PrgX/pheromone complexes and regulation of conjugation in Enterococcus faecalis.
Shi K, Brown CK, Gu ZY, Kozlowicz BK, Dunny GM, Ohlendorf DH, Earhart CA
Proc Natl Acad Sci U S A 102 18596-601 (2005)
PMID: 16339309

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162631 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
HTH cro/C1-type domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 317 amino acids
Theoretical weight: 37.14 KDa
Source organism: Enterococcus faecalis
Expression system: Escherichia coli
UniProt:
  • Canonical: Q04114 (Residues: 1-317; Coverage: 100%)
Gene name: prgX
Sequence domains:
Structure domains:
peptide Chains: E, F
Molecule details ›
Chains: E, F
Length: 7 amino acids
Theoretical weight: 790 Da
Source organism: Enterococcus faecalis
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P6122
Unit cell:
a: 82.546Å b: 82.546Å c: 380.156Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.214 0.212 0.26
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

18 review citations

Antibiotic resistant enterococci-tales of a drug resistance gene trafficker.
Werner et al. (2013)
17 more

2 mentions without citation

Structure of peptide sex pheromone receptor PrgX and PrgX/pheromone complexes and regulation of conjugation in Enterococcus faecalis.
Shi et al. (2005)
1 more