› 2awx

X-ray diffraction
1.8Å resolution

Synapse associated protein 97 PDZ2 domain variant C378S

Released:
DOI: 10.2210/pdb2awx/pdb
PDB entry 2awx coloured by chain, front view.
PDB entry 2awx coloured by chain, side view.
PDB entry 2awx coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structure of the second PDZ domain of SAP97 in complex with a GluR-A C-terminal peptide.
von Ossowski I, Oksanen E, von Ossowski L, Cai C, Sundberg M, Goldman A, Keinänen K
FEBS J 273 5219-29 (2006)
PMID: 17069616

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178959 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Disks large homolog 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 105 amino acids
Theoretical weight: 11.46 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q62696 (Residues: 314-409; Coverage: 11%)
Gene names: Dlg1, Dlgh1
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

1 bound ligand:
Ligand HIS 2 x HIS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: P21
Unit cell:
a: 32.3Å b: 52.43Å c: 52.92Å
α: 90° β: 102.72° γ: 90°
R-values:
R R work R free
0.191 0.188 0.254
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Ligand binding by PDZ domains.
Chi et al. (2012)
3 more

5 mentions without citation

Change in allosteric network affects binding affinities of PDZ domains: analysis through perturbation response scanning.
Gerek et al. (2011)
4 more