› 2b0t

X-ray diffraction
1.75Å resolution

Structure of Monomeric NADP Isocitrate dehydrogenase

Released:
DOI: 10.2210/pdb2b0t/pdb
PDB entry 2b0t coloured by chain, front view.
PDB entry 2b0t coloured by chain, side view.
PDB entry 2b0t coloured by chain, top view.
Source organism: Corynebacterium glutamicum
Primary publication:
Substrate-free structure of a monomeric NADP isocitrate dehydrogenase: an open conformation phylogenetic relationship of isocitrate dehydrogenase.
Imabayashi F, Aich S, Prasad L, Delbaere LT
Proteins 63 100-12 (2006)
PMID: 16416443

Function and Biology Details

Reaction catalysed: 
(1a) isocitrate + NADP(+) = 2-oxalosuccinate + NADPH
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156146 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Isocitrate dehydrogenase [NADP] Chain: A
Molecule details ›
Chain: A
Length: 738 amino acids
Theoretical weight: 80.17 KDa
Source organism: Corynebacterium glutamicum
UniProt:
  • Canonical: P50216 (Residues: 1-738; Coverage: 100%)
Gene names: Cgl0664, cg0766, icd
Sequence domains: Monomeric isocitrate dehydrogenase

Ligands and Environments

1 bound ligand:
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-ID-B
Spacegroup: C2
Unit cell:
a: 129.046Å b: 52.692Å c: 124.035Å
α: 90° β: 108.98° γ: 90°
R-values:
R R work R free
0.2 0.2 0.23

Quick links

Citations

1 review citation

Recent advances of IDH1 mutant inhibitor in cancer therapy.
Tian et al. (2022)
16 other articles

6 mentions without citation

Self-association of a highly charged arginine-rich cell-penetrating peptide.
Tesei et al. (2017)
5 more