› 2b4i

X-ray diffraction
2Å resolution

Crystal Structure of the Rhesus Rotavirus VP5 Antigen Domain Trimer

Released:
DOI: 10.2210/pdb2b4i/pdb
PDB entry 2b4i coloured by chain, front view.
PDB entry 2b4i coloured by chain, side view.
PDB entry 2b4i coloured by chain, top view.
Source organism: Simian rotavirus A strain RRV
Primary publication:
Alternative intermolecular contacts underlie the rotavirus VP5* two- to three-fold rearrangement.
Yoder JD, Dormitzer PR
EMBO J 25 1559-68 (2006)
PMID: 16511559

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146169 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Outer capsid protein VP5* Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 254 amino acids
Theoretical weight: 28.52 KDa
Source organism: Simian rotavirus A strain RRV
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P12473 (Residues: 247-479; Coverage: 30%)
Sequence domains: Rotavirus VP4 membrane interaction domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P212121
Unit cell:
a: 93.123Å b: 94.027Å c: 97.503Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.222 0.252
Expression system: Spodoptera frugiperda

Quick links

Citations

3 review citations

Structure-based antigen design: a strategy for next generation vaccines.
Dormitzer et al. (2008)
2 more

3 mentions without citation

Comparative genomic analysis of genogroup 1 (Wa-like) rotaviruses circulating in the USA, 2006-2009.
Roy et al. (2014)
2 more