› 2b69

X-ray diffraction
1.21Å resolution

Crystal Structure of Human UDP-glucoronic acid decarboxylase

Released:
DOI: 10.2210/pdb2b69/pdb
PDB entry 2b69 coloured by chain, front view.
PDB entry 2b69 coloured by chain, side view.
PDB entry 2b69 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ugochukwu E, Dubinina E, Kavanagh K, Sundstrom M, Weigelt J, Edwards A, Arrowsmith C, von Delft F, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
UDP-D-glucuronate = UDP-D-xylose + CO(2)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185481 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
UDP-glucuronic acid decarboxylase 1 Chain: A
Molecule details ›
Chain: A
Length: 343 amino acids
Theoretical weight: 39.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8NBZ7 (Residues: 85-402; Coverage: 76%)
Gene names: UNQ2538/PRO6079, UXS1
Sequence domains: GDP-mannose 4,6 dehydratase
Structure domains:

Ligands and Environments


Cofactor: Ligand NAD 1 x NAD
1 bound ligand:
Ligand UDP 2 x UDP
1 modified residue:
Ligand MSE 12 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P2
Unit cell:
a: 46Å b: 45Å c: 85Å
α: 90° β: 97° γ: 90°
R-values:
R R work R free
0.136 0.134 0.162
Expression system: Escherichia coli

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