› 2b8a

Solution NMR

High Resolution Structure of the HDGF PWWP Domain

Released:
DOI: 10.2210/pdb2b8a/pdb
PDB entry 2b8a coloured by chain, ensemble of 26 models, front view.
PDB entry 2b8a coloured by chain, ensemble of 26 models, side view.
PDB entry 2b8a coloured by chain, ensemble of 26 models, top view.
Source organism: Rattus norvegicus
Primary publication:
High resolution structure of the HDGF PWWP domain: a potential DNA binding domain.
Lukasik SM, Cierpicki T, Borloz M, Grembecka J, Everett A, Bushweller JH
Protein Sci 15 314-23 (2006)
PMID: 16384999

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186584 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatoma-derived growth factor Chain: A
Molecule details ›
Chain: A
Length: 110 amino acids
Theoretical weight: 12.64 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8VHK7 (Residues: 1-110; Coverage: 46%)
Gene name: Hdgf
Sequence domains: PWWP domain
Structure domains: SH3 type barrels.

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Mammalian DNA methyltransferases: a structural perspective.
Cheng et al. (2008)
9 more

4 mentions without citation

PWWP domains and their modes of sensing DNA and histone methylated lysines.
Rona et al. (2016)
3 more