› 2b9d

X-ray diffraction
1.6Å resolution

Crystal Structure of HPV E7 CR3 domain

Released:
DOI: 10.2210/pdb2b9d/pdb
PDB entry 2b9d coloured by chain, front view.
PDB entry 2b9d coloured by chain, side view.
PDB entry 2b9d coloured by chain, top view.
Source organism: Human papillomavirus type 1a
Primary publication:
Structure of the human Papillomavirus E7 oncoprotein and its mechanism for inactivation of the retinoblastoma tumor suppressor.
Liu X, Clements A, Zhao K, Marmorstein R
J Biol Chem 281 578-86 (2006)
PMID: 16249186

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139054 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein E7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 52 amino acids
Theoretical weight: 5.93 KDa
Source organism: Human papillomavirus type 1a
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P06465 (Residues: 44-93; Coverage: 54%)
Gene name: E7
Sequence domains: E7 protein, Early protein
Structure domains: Double Stranded RNA Binding Domain

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21212
Unit cell:
a: 33.908Å b: 44.935Å c: 58.67Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.208 0.252
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

31 review citations

The human papillomavirus E7 oncoprotein.
McLaughlin-Drubin et al. (2009)
30 more

9 mentions without citation

The critical protein interactions and structures that elicit growth deregulation in cancer and viral replication.
Ou et al. (2011)
8 more