› 2bbo

X-ray diffraction
2.55Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146638 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cystic fibrosis transmembrane conductance regulator Chain: A
Molecule details ›
Chain: A
Length: 291 amino acids
Theoretical weight: 32.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13569 (Residues: 388-678; Coverage: 20%)
Gene names: ABCC7, CFTR
Sequence domains: ABC transporter
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand ATP 1 x ATP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P43212
Unit cell:
a: 57.836Å b: 57.836Å c: 141.303Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.23 0.274
Expression system: Escherichia coli

Quick links

Citations

17 review citations

CFTR: folding, misfolding and correcting the ΔF508 conformational defect.
Lukacs et al. (2012)
16 more

24 mentions without citation

Cystic fibrosis transmembrane conductance regulator (ABCC7) structure.
Hunt et al. (2013)
23 more