› 2bbr

X-ray diffraction
1.2Å resolution

Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition

Released:
DOI: 10.2210/pdb2bbr/pdb
PDB entry 2bbr coloured by chain, front view.
PDB entry 2bbr coloured by chain, side view.
PDB entry 2bbr coloured by chain, top view.
Source organism: Molluscum contagiosum virus subtype 1
Primary publication:
Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition.
Yang JK, Wang L, Zheng L, Wan F, Ahmed M, Lenardo MJ, Wu H
Mol Cell 20 939-49 (2005)
PMID: 16364918

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189115 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Viral CASP8 and FADD-like apoptosis regulator Chain: A
Molecule details ›
Chain: A
Length: 195 amino acids
Theoretical weight: 22.17 KDa
Source organism: Molluscum contagiosum virus subtype 1
Expression system: Escherichia coli
UniProt:
  • Canonical: Q98325 (Residues: 1-187; Coverage: 78%)
Gene names: H-H2.2, MC159L
Sequence domains: Death effector domain
Structure domains: Death Domain, Fas

Ligands and Environments

1 bound ligand:
Ligand AZI 1 x AZI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P212121
Unit cell:
a: 34.979Å b: 62.867Å c: 75.806Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.211 0.226
Expression system: Escherichia coli

Quick links

Citations

27 review citations

The apoptosome: signalling platform of cell death.
Riedl et al. (2007)
26 more

12 mentions without citation

Structural basis of signal transduction in the TNF receptor superfamily.
Li et al. (2013)
11 more