› 2bbu

Solution NMR

solution structure of mouse socs3 in complex with a phosphopeptide from the gp130 receptor

Released:
DOI: 10.2210/pdb2bbu/pdb
PDB entry 2bbu coloured by chain, ensemble of 20 models, front view.
PDB entry 2bbu coloured by chain, ensemble of 20 models, side view.
PDB entry 2bbu coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability.
Babon JJ, McManus EJ, Yao S, DeSouza DP, Mielke LA, Sprigg NS, Willson TA, Hilton DJ, Nicola NA, Baca M, Nicholson SE, Norton RS
Mol Cell 22 205-16 (2006)
PMID: 16630890

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128710 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Suppressor of cytokine signaling 3 Chain: A
Molecule details ›
Chain: A
Length: 164 amino acids
Theoretical weight: 17.96 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O35718 (Residues: 22-185; Coverage: 73%)
Gene names: Cis3, Cish3, Socs3
Sequence domains: SH2 domain
Structure domains: SH2 domain
Interleukin-6 receptor subunit beta Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 1.61 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q00560 (Residues: 750-764; Coverage: 2%)
Gene name: Il6st

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing distance geometry torsion angle dynamics
Expression systems:
  • Escherichia coli BL21
  • Not provided

Quick links

Citations

37 review citations

SOCS proteins, cytokine signalling and immune regulation.
Yoshimura et al. (2007)
36 more

6 mentions without citation

Loops govern SH2 domain specificity by controlling access to binding pockets.
Kaneko et al. (2010)
5 more