2bc4

X-ray diffraction
2.27Å resolution

Crystal structure of HLA-DM

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
PDBe Complex ID:
PDB-CPX-151165 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class II histocompatibility antigen, DM alpha chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 211 amino acids
Theoretical weight: 23.99 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P28067 (Residues: 27-229; Coverage: 86%)
Gene names: DMA, HLA-DMA, RING6
Sequence domains:
Structure domains:
HLA class II histocompatibility antigen, DM beta chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 211 amino acids
Theoretical weight: 23.58 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P28068 (Residues: 19-218; Coverage: 82%)
Gene names: DMB, HLA-DMB, RING7
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, NDG, BMA
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P212121
Unit cell:
a: 98.068Å b: 108.42Å c: 110.207Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.261 0.229 0.268
Expression system: Drosophila melanogaster