› 2be1

X-ray diffraction
2.98Å resolution

Structure of the compact lumenal domain of yeast Ire1

Released:
DOI: 10.2210/pdb2be1/pdb
PDB entry 2be1 coloured by chain, front view.
PDB entry 2be1 coloured by chain, side view.
PDB entry 2be1 coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
On the mechanism of sensing unfolded protein in the endoplasmic reticulum.
Credle JJ, Finer-Moore JS, Papa FR, Stroud RM, Walter P
Proc Natl Acad Sci U S A 102 18773-84 (2005)
PMID: 16365312

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152279 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine/threonine-protein kinase/endoribonuclease IRE1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 339 amino acids
Theoretical weight: 38.13 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: P32361 (Residues: 111-449; Coverage: 31%)
Gene names: ERN1, IRE1, YHR079C
peptide Chain: D
Molecule details ›
Chain: D
Length: 8 amino acids
Theoretical weight: 811 Da
Source organism: Saccharomyces cerevisiae
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P6522
Unit cell:
a: 103.3Å b: 103.3Å c: 401.4Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.244 0.24 0.279
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

140 review citations

Signal integration in the endoplasmic reticulum unfolded protein response.
Ron et al. (2007)
139 more

11 mentions without citation

Mechanisms, regulation and functions of the unfolded protein response.
Hetz et al. (2020)
10 more