Function and Biology Details
Reactions catalysed:
Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate
Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Protein farnesyltransferase complex (preferred)
PDBe Complex ID:
PDB-CPX-169704 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Molecule details ›
Chain: A
Length: 313 amino acids
Theoretical weight: 37.69 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
Sequence domains: Protein prenyltransferase alpha subunit repeat
Structure domains: Protein prenylyltransferase
Length: 313 amino acids
Theoretical weight: 37.69 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
- Canonical:
Q04631 (Residues: 54-366; Coverage: 83%)
Sequence domains: Protein prenyltransferase alpha subunit repeat
Structure domains: Protein prenylyltransferase
Protein farnesyltransferase subunit beta
Molecule details ›
Chain: B
Length: 401 amino acids
Theoretical weight: 44.88 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
Sequence domains: Prenyltransferase and squalene oxidase repeat
Structure domains: Glycosyltransferase
Length: 401 amino acids
Theoretical weight: 44.88 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
- Canonical: Q02293 (Residues: 23-423; Coverage: 92%)
Sequence domains: Prenyltransferase and squalene oxidase repeat
Structure domains: Glycosyltransferase
