› 2bfr

X-ray diffraction
2.5Å resolution

The Macro domain is an ADP-ribose binding module

Released:
DOI: 10.2210/pdb2bfr/pdb
PDB entry 2bfr coloured by chain, front view.
PDB entry 2bfr coloured by chain, side view.
PDB entry 2bfr coloured by chain, top view.
Source organism: Archaeoglobus fulgidus
Primary publication:
The macro domain is an ADP-ribose binding module.
Karras GI, Kustatscher G, Buhecha HR, Allen MD, Pugieux C, Sait F, Bycroft M, Ladurner AG
EMBO J 24 1911-20 (2005)
PMID: 15902274

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128057 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ADP-ribose glycohydrolase AF_1521 Chain: A
Molecule details ›
Chain: A
Length: 192 amino acids
Theoretical weight: 21.01 KDa
Source organism: Archaeoglobus fulgidus
Expression system: Escherichia coli
UniProt:
  • Canonical: O28751 (Residues: 1-192; Coverage: 100%)
Gene name: AF_1521
Sequence domains: Macro domain
Structure domains: Leucine Aminopeptidase, subunit E, domain 1

Ligands and Environments

2 bound ligands:
Ligand ADP 1 x ADP
Ligand MG 1 x MG
1 modified residue:
Ligand FME 1 x FME

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P61
Unit cell:
a: 87.84Å b: 87.84Å c: 61.069Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.202 0.237
Expression system: Escherichia coli

Quick links

Citations

103 review citations

Poly(ADP-ribose): novel functions for an old molecule.
Schreiber et al. (2006)
102 more

4 mentions without citation

The macro domain is an ADP-ribose binding module.
Karras et al. (2005)
3 more