› 2bgk

X-ray diffraction
1.6Å resolution

Function and Biology Details

Reaction catalysed: 
(-)-secoisolariciresinol + 2 NAD(+) = (-)-matairesinol + 2 NADH
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188242 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Secoisolariciresinol dehydrogenase Chains: A, B
Molecule details ›
Chains: A, B
Length: 278 amino acids
Theoretical weight: 29.29 KDa
Source organism: Podophyllum peltatum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q94KL8 (Residues: 1-278; Coverage: 100%)
Sequence domains: Enoyl-(Acyl carrier protein) reductase
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: C2221
Unit cell:
a: 107.34Å b: 133.56Å c: 69.35Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.197 0.226
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Dissection of lignin macromolecular configuration and assembly: comparison to related biochemical processes in allyl/propenyl phenol and lignan biosynthesis.
Davin et al. (2008)
1 more

2 mentions without citation

Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis.
Lichman et al. (2019)
1 more