› 2biv

X-ray diffraction
1.7Å resolution

Crystal structure of the wild-type MBT domains of Human SCML2

Released:
DOI: 10.2210/pdb2biv/pdb
PDB entry 2biv coloured by chain, front view.
PDB entry 2biv coloured by chain, side view.
PDB entry 2biv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The malignant brain tumor repeats of human SCML2 bind to peptides containing monomethylated lysine.
Santiveri CM, Lechtenberg BC, Allen MD, Sathyamurthy A, Jaulent AM, Freund SM, Bycroft M
J Mol Biol 382 1107-12 (2008)
PMID: 18706910

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194074 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sex comb on midleg-like protein 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 243 amino acids
Theoretical weight: 27.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UQR0 (Residues: 1-243; Coverage: 35%)
Gene name: SCML2
Sequence domains: mbt repeat
Structure domains: SH3 type barrels.

Ligands and Environments

2 bound ligands:
Ligand IOD 10 x IOD
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX10.1
Spacegroup: P212121
Unit cell:
a: 40.02Å b: 88.206Å c: 186.988Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.198 0.229
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

Biochemical mechanisms of gene regulation by polycomb group protein complexes.
Müller et al. (2009)
6 more

5 mentions without citation

Which Is Stronger? A Continuing Battle Between Cry Toxins and Insects.
Liu et al. (2021)
4 more