› 2bj0

X-ray diffraction
2Å resolution

Crystal Structure of AChBP from Bulinus truncatus revals the conserved structural scaffold and sites of variation in nicotinic acetylcholine receptors

Released:
DOI: 10.2210/pdb2bj0/pdb
PDB entry 2bj0 coloured by chain, front view.
PDB entry 2bj0 coloured by chain, side view.
PDB entry 2bj0 coloured by chain, top view.
Source organism: Bulinus truncatus
Primary publication:
Crystal structure of acetylcholine-binding protein from Bulinus truncatus reveals the conserved structural scaffold and sites of variation in nicotinic acetylcholine receptors.
Celie PH, Klaassen RV, van Rossum-Fikkert SE, van Elk R, van Nierop P, Smit AB, Sixma TK
J Biol Chem 280 26457-66 (2005)
PMID: 15899893

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162648 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ACETYLCHOLINE-BINDING PROTEIN Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 203 amino acids
Theoretical weight: 22.91 KDa
Source organism: Bulinus truncatus
Expression system: Spodoptera frugiperda
Structure domains: Neurotransmitter-gated ion-channel ligand-binding domain

Ligands and Environments

1 bound ligand:
Ligand CXS 4 x CXS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: C2221
Unit cell:
a: 76.945Å b: 219.018Å c: 166.965Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.21 0.249
Expression system: Spodoptera frugiperda

Quick links

Citations

30 review citations

Brain nicotinic acetylcholine receptors: native subtypes and their relevance.
Gotti et al. (2006)
29 more

12 mentions without citation

In Silico Studies in Drug Research Against Neurodegenerative Diseases.
Makhouri et al. (2018)
11 more