› 2bka

X-ray diffraction
1.7Å resolution

CC3(TIP30)Crystal Structure

Released:
DOI: 10.2210/pdb2bka/pdb
PDB entry 2bka coloured by chain, front view.
PDB entry 2bka coloured by chain, side view.
PDB entry 2bka coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor.
El Omari K, Bird LE, Nichols CE, Ren J, Stammers DK
J Biol Chem 280 18229-36 (2005)
PMID: 15728189

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189743 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Oxidoreductase HTATIP2 Chain: A
Molecule details ›
Chain: A
Length: 242 amino acids
Theoretical weight: 27.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9BUP3 (Residues: 1-242; Coverage: 100%)
Gene names: CC3, HTATIP2, TIP30
Sequence domains: NAD(P)H-binding
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments

4 bound ligands:
Ligand NDP 1 x NDP
Ligand PE8 1 x PE8
Ligand GOL 2 x GOL
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.2
Spacegroup: P3221
Unit cell:
a: 68.14Å b: 68.14Å c: 119.2Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.166 0.166 0.191
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes.
Kavanagh et al. (2008)
3 more

4 mentions without citation

Alternative splicing and protein structure evolution.
Birzele et al. (2008)
3 more