› 2bm7

X-ray diffraction
2.7Å resolution

The Structure of MfpA (Rv3361c, P3221 Crystal form). The Pentapeptide Repeat Protein from Mycobacterium tuberculosis Folds as A Right- handed Quadrilateral Beta-helix.

Released:
DOI: 10.2210/pdb2bm7/pdb
PDB entry 2bm7 coloured by chain, front view.
PDB entry 2bm7 coloured by chain, side view.
PDB entry 2bm7 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Primary publication:
A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA.
Hegde SS, Vetting MW, Roderick SL, Mitchenall LA, Maxwell A, Takiff HE, Blanchard JS
Science 308 1480-3 (2005)
PMID: 15933203

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129325 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pentapeptide repeat family protein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 186 amino acids
Theoretical weight: 20.33 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: O50390 (Residues: 1-183; Coverage: 100%)
Gene name: MT3469
Sequence domains:
Structure domains: E3 ubiquitin-protein ligase SopA

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P3221
Unit cell:
a: 84.08Å b: 84.08Å c: 147.122Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.229 0.229 0.289
Expression system: Escherichia coli

Quick links

Citations

58 review citations

Persister cells, dormancy and infectious disease.
Lewis K. (2007)
57 more

2 mentions without citation

Role of a qnr-like gene in the intrinsic resistance of Enterococcus faecalis to fluoroquinolones.
Arsène et al. (2007)
1 more