› 2bph

X-ray diffraction
2.2Å resolution

STRUCTURE OF MURINE DECTIN-1

Released:
DOI: 10.2210/pdb2bph/pdb
PDB entry 2bph coloured by chain, front view.
PDB entry 2bph coloured by chain, side view.
PDB entry 2bph coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure of the fungal beta-glucan-binding immune receptor dectin-1: implications for function.
Brown J, O'Callaghan CA, Marshall AS, Gilbert RJ, Siebold C, Gordon S, Brown GD, Jones EY
Protein Sci 16 1042-52 (2007)
PMID: 17473009

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180274 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-type lectin domain family 7 member A Chains: A, B
Molecule details ›
Chains: A, B
Length: 140 amino acids
Theoretical weight: 16.23 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6QLQ4 (Residues: 113-244; Coverage: 54%)
Gene names: Bgr, Clec7a, Clecsf12, Dectin1
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

1 bound ligand:
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: P32
Unit cell:
a: 57.199Å b: 57.199Å c: 72.996Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.198 0.195 0.254
Expression system: Escherichia coli

Quick links

Citations

27 review citations

Beta-glucan recognition by the innate immune system.
Goodridge et al. (2009)
26 more

2 mentions without citation

Classification and energetics of the base-phosphate interactions in RNA.
Zirbel et al. (2009)
1 more