› 2bq2

Solution NMR

Solution Structure of the DNA Duplex ACGCGU-NA with a 2' Amido-Linked Nalidixic Acid Residue at the 3' Terminal Nucleotide

Released:
DOI: 10.2210/pdb2bq2/pdb
PDB entry 2bq2 coloured by chain, ensemble of 2 models, front view.
PDB entry 2bq2 coloured by chain, ensemble of 2 models, side view.
PDB entry 2bq2 coloured by chain, ensemble of 2 models, top view.
Source organism: Synthetic construct
Primary publication:
Molecular details of quinolone-DNA interactions: solution structure of an unusually stable DNA duplex with covalently linked nalidixic acid residues and non-covalent complexes derived from it.
Siegmund K, Maheshwary S, Narayanan S, Connors W, Riedrich M, Printz M, Richert C
Nucleic Acids Res 33 4838-48 (2005)
PMID: 16126848

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115123 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*AP*CP*GP*CP*GP*2AU)-3' Chains: A, B
Molecule details ›
Chains: A, B
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand NIX 2 x NIX
1 modified residue:
Ligand 2AU 2 x 2AU

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

2 review citations

DNA-binding drugs caught in action: the latest 3D pictures of drug-DNA complexes.
Boer et al. (2009)
1 more

1 mention without citation

3dDNA: A Computational Method of Building DNA 3D Structures.
Zhang et al. (2022)