2buo

X-ray diffraction
1.7Å resolution

HIV-1 capsid C-terminal domain in complex with an inhibitor of particle assembly

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-136813 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Capsid protein p24 Chain: A
Molecule details ›
Chain: A
Length: 86 amino acids
Theoretical weight: 9.53 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03347 (Residues: 278-363; Coverage: 17%)
Gene name: gag
Sequence domains: Gag protein p24 C-terminal domain
Structure domains: Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A
INHIBITOR OF CAPSID ASSEMBLY Chain: T
Molecule details ›
Chain: T
Length: 12 amino acids
Theoretical weight: 1.45 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: P41212
Unit cell:
a: 42.541Å b: 42.541Å c: 90.903Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.224 0.234
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided