› 2bw1

X-ray diffraction
1.81Å resolution

Iron-bound crystal structure of Dps-like peroxide resistance protein (Dpr) from Streptococcus suis.

Released:
DOI: 10.2210/pdb2bw1/pdb
PDB entry 2bw1 coloured by chain, front view.
PDB entry 2bw1 coloured by chain, side view.
PDB entry 2bw1 coloured by chain, top view.
Source organism: Streptococcus suis
Primary publication:
Iron incorporation in Streptococcus suis Dps-like peroxide resistance protein Dpr requires mobility in the ferroxidase center and leads to the formation of a ferrihydrite-like core.
Kauko A, Pulliainen AT, Haataja S, Meyer-Klaucke W, Finne J, Papageorgiou AC
J Mol Biol 364 97-109 (2006)
PMID: 16997323

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143201 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA protection during starvation protein Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 165 amino acids
Theoretical weight: 18.57 KDa
Source organism: Streptococcus suis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P0CB53 (Residues: 9-172, 8-172; Coverage: 96%)
Gene names: dpr, dps
Sequence domains: Ferritin-like domain
Structure domains: Ferritin

Ligands and Environments

3 bound ligands:
Ligand EPE 4 x EPE
Ligand FE 12 x FE
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P212121
Unit cell:
a: 105.13Å b: 138.05Å c: 142.55Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.187 0.23
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Dps-like proteins: structural and functional insights into a versatile protein family.
Haikarainen et al. (2010)
3 more

1 mention without citation

Structural basis of the zinc- and terbium-mediated inhibition of ferroxidase activity in Dps ferritin-like proteins.
Havukainen et al. (2008)