› 2byo

X-ray diffraction
2.15Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161725 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Putative phthiocerol dimycocerosate transporter LppX Chain: A
Molecule details ›
Chain: A
Length: 207 amino acids
Theoretical weight: 21.53 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P9WK65 (Residues: 27-233; Coverage: 100%)
Gene names: MTCY24G1.04, Rv2945c, lppX
Sequence domains: LppX_LprAFG lipoprotein
Structure domains: outer membrane lipoprotein receptor (LolB), chain A

Ligands and Environments

6 bound ligands:
Ligand ZN 6 x ZN
Ligand ACT 1 x ACT
Ligand HXA 1 x HXA
Ligand LNL 2 x LNL
Ligand OAA 1 x OAA
Ligand MLT 1 x MLT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P6522
Unit cell:
a: 54.257Å b: 54.257Å c: 269.983Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.189 0.185 0.224
Expression system: Escherichia coli BL21

Quick links

Citations

19 review citations

Virulence factors of the Mycobacterium tuberculosis complex.
Forrellad et al. (2013)
18 more

6 mentions without citation

LppX is a lipoprotein required for the translocation of phthiocerol dimycocerosates to the surface of Mycobacterium tuberculosis.
Sulzenbacher et al. (2006)
5 more