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X-ray diffraction
1.65Å resolution

CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE N14 AT 1. 65 A RESOLUTION

Released:
DOI: 10.2210/pdb2bzl/pdb
Model geometry
Fit model/data
PDB entry 2bzl coloured by chain, front view.
PDB entry 2bzl coloured by chain, side view.
PDB entry 2bzl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution.
Barr AJ, Debreczeni JE, Eswaran J, Knapp S
Proteins 63 1132-6 (2006)
PMID: 16534812

Function and Biology Details

Reaction catalysed: 
O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172373 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 14 Chain: A
Molecule details ›
Chain: A
Length: 325 amino acids
Theoretical weight: 37.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15678 (Residues: 871-1187; Coverage: 27%)
Gene names: PEZ, PTPD2, PTPN14
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

2 bound ligands:
Ligand SO4 2 x SO4
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P3221
Unit cell:
a: 87.636Å b: 87.636Å c: 77.115Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.186 0.185 0.217
Expression system: Escherichia coli BL21(DE3)

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Citations

9 citation in other articles

Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Barr et al. (2009)
8 more

2 mentions without citation

Structural basis for recognition of the tumor suppressor protein PTPN14 by the oncoprotein E7 of human papillomavirus.
Yun et al. (2019)
1 more