› 2c0d

X-ray diffraction
1.78Å resolution

Structure of the mitochondrial 2-cys peroxiredoxin from Plasmodium falciparum

Released:
DOI: 10.2210/pdb2c0d/pdb
PDB entry 2c0d coloured by chain, front view.
PDB entry 2c0d coloured by chain, side view.
PDB entry 2c0d coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Primary publication:
Structural and biochemical characterization of a mitochondrial peroxiredoxin from Plasmodium falciparum.
Boucher IW, McMillan PJ, Gabrielsen M, Akerman SE, Brannigan JA, Schnick C, Brzozowski AM, Wilkinson AJ, Müller S
Mol Microbiol 61 948-59 (2006)
PMID: 16879648

Function and Biology Details

Reaction catalysed: 
Thioredoxin + ROOH = thioredoxin disulfide + H(2)O + ROH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184693 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
thioredoxin-dependent peroxiredoxin Chains: A, B
Molecule details ›
Chains: A, B
Length: 221 amino acids
Theoretical weight: 25.29 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q8I5Q6 (Residues: 18-216; Coverage: 92%)
Gene name: PF3D7_1215000
Sequence domains:
Structure domains: Glutaredoxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: C2
Unit cell:
a: 104.632Å b: 76.534Å c: 60.154Å
α: 90° β: 113.34° γ: 90°
R-values:
R R work R free
0.167 0.165 0.204
Expression system: Escherichia coli BL21

Quick links

Citations

8 review citations

Plasmodium nesting: remaking the erythrocyte from the inside out.
Boddey et al. (2013)
7 more

10 mentions without citation

Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins.
Hall et al. (2011)
9 more