› 2c36

X-ray diffraction
2.11Å resolution

Structure of unliganded HSV gD reveals a mechanism for receptor- mediated activation of virus entry

Released:
DOI: 10.2210/pdb2c36/pdb
PDB entry 2c36 coloured by chain, front view.
PDB entry 2c36 coloured by chain, side view.
PDB entry 2c36 coloured by chain, top view.
Source organism: Human alphaherpesvirus 1
Primary publication:
Structure of unliganded HSV gD reveals a mechanism for receptor-mediated activation of virus entry.
Krummenacher C, Supekar VM, Whitbeck JC, Lazear E, Connolly SA, Eisenberg RJ, Cohen GH, Wiley DC, Carfí A
EMBO J 24 4144-53 (2005)
PMID: 16292345

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157599 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Envelope glycoprotein D Chains: A, B
Molecule details ›
Chains: A, B
Length: 285 amino acids
Theoretical weight: 31.56 KDa
Source organism: Human alphaherpesvirus 1
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P57083 (Residues: 48-332; Coverage: 77%)
Gene names: US6, gD
Sequence domains: Herpesvirus glycoprotein D/GG/GX domain
Structure domains: Glycoprotein D; Chain: A;

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
2 bound ligands:
Ligand ZN 1 x ZN
Ligand CL 3 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-D
Spacegroup: P212121
Unit cell:
a: 74.252Å b: 106.193Å c: 130.315Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.194 0.247
Expression system: Spodoptera frugiperda

Quick links

Citations

29 review citations

Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme.
White et al. (2008)
28 more

22 mentions without citation

Herpes virus fusion and entry: a story with many characters.
Eisenberg et al. (2012)
21 more