› 2c4k

X-ray diffraction
2.65Å resolution

Crystal structure of human phosphoribosylpyrophosphate synthetase- associated protein 39 (PAP39)

Released:
DOI: 10.2210/pdb2c4k/pdb
PDB entry 2c4k coloured by chain, front view.
PDB entry 2c4k coloured by chain, side view.
PDB entry 2c4k coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kursula P, Stenmark P, Arrowsmith C, Berglund H, Edwards A, Ehn M, Flodin S, Graslund S, Hammarstrom M, Hallberg BM, Holmberg Schiavone L, Kotenyova T, Nilsson-Ehle P, Ogg D, Persson C, Sagemark J, Schuler H, Sundstrom M, Thorsell AG, Van Den Berg S, Weigelt J, Nordlund P

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172029 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphoribosyl pyrophosphate synthase-associated protein 1 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 370 amino acids
Theoretical weight: 41.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14558 (Residues: 1-351; Coverage: 99%)
Gene name: PRPSAP1
Sequence domains:
Structure domains: Rossmann fold

Ligands and Environments

2 bound ligands:
Ligand SO4 7 x SO4
Ligand TAM 1 x TAM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I711
Spacegroup: C2
Unit cell:
a: 180.055Å b: 103.875Å c: 127.161Å
α: 90° β: 97.63° γ: 90°
R-values:
R R work R free
0.271 0.269 0.299
Expression system: Escherichia coli BL21(DE3)

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