› 2c9h

X-ray diffraction
1.8Å resolution

Structure of mitochondrial beta-ketoacyl synthase

Released:
DOI: 10.2210/pdb2c9h/pdb
PDB entry 2c9h coloured by chain, front view.
PDB entry 2c9h coloured by chain, side view.
PDB entry 2c9h coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Bunkoczi G, Wu X, Smee C, Gileadi O, Arrowsmith C, Edwards A, Sundstrom M, Weigelt J, von Delft F, Oppermann U

Function and Biology Details

Reaction catalysed: 
Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192662 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 444 amino acids
Theoretical weight: 47.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NWU1 (Residues: 39-459; Coverage: 92%)
Gene name: OXSM
Sequence domains:
Structure domains: Peroxisomal Thiolase; Chain A, domain 1

Ligands and Environments

1 bound ligand:
Ligand NI 1 x NI
1 modified residue:
Ligand CSD 1 x CSD

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21212
Unit cell:
a: 116.725Å b: 58.056Å c: 58.987Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.177 0.24
Expression system: Escherichia coli BL21(DE3)

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